Phenotype Image Detail

Image

Caption

(A and B) Scanning electron microscopy analysis in P5 wild-type (wt) and Cdh23^sals/Cdh23^sals (salsa) mice revealed tip tenting in stereocilia of cochlear hair cells (arrowheads). (C and D) Defects in tenting in mutant mice at P60 (arrowheads in C indicater tenting in wild-type). (E-G) Tips in vestibular hair cells display normal tenting. Tip links (arrowhead in G) were preserved. (H) Quantification of tip tenting at P5 and P21. Tenting was reduced in hair cells from the medial and basal cochlear turns at P21. *, P<0.05. [Scale bars: A-D 300 nm; E and F 500 nm; G 150 nm].

Copyright

This image is from Schwander M, Proc Natl Acad Sci U S A 2009 Mar 31;106(13):5252-7. Copyright 2009 National Academy of Sciences, U.S.A. J:147149

Associated Alleles

Symbol	Name
Cdh23^sals	cadherin related 23 (otocadherin); salsa