Phenotype Image Detail

Image

Caption

(A-D) Shown are the Alizarin red-stained humerus (A), radius and ulna (B), femur (C), and tibia (D) of 5 month old WT, Fgfr3^tm1Schl/Fgfr3^tm1Schl (Fgfr3b^-/-) and Fgfr3^tm2Schl/Fgfr3^tm2Schl (Fgfr3c^-/-) mice. Note the elongation of the bones in the Fgfr3^tm2Schl/Fgfr3^tm2Schl mice. (E) Histogram of the lengths of the appendicular bones. Values are expressed in millimeters. Sample sizes: WT, n=10; Fgfr3^tm1Schl/Fgfr3^tm1Schl, n=5; Fgfr3^tm2Schl/Fgfr3^tm2Schl, n=5. Note the significant difference between wild-type and Fgfr3^tm2Schl/Fgfr3^tm2Schl bones. *, P<0.00001 by paired t test.

Copyright

This image is from Eswarakumar VP, Proc Natl Acad Sci U S A 2007 Mar 6;104(10):3937-42. Copyright 2007 National Academy of Sciences, U.S.A. J:142946

Associated Alleles

Symbol	Name
Fgfr3^tm1Schl	fibroblast growth factor receptor 3; targeted mutation 1, Joseph Schlessinger
Fgfr3^tm2Schl	fibroblast growth factor receptor 3; targeted mutation 2, Joseph Schlessinger