Phenotype Image Detail

Image

Caption

(A) Three-dimensional reconstruction of the femoral cortical bones. Cortical measurements are an average of 50 slices (600 um), taken 50% of diaphysis length, from proximal growth plate (GP) to distal GP. Note the thin cortical bone of wild-type, Fgfr3^tm2Schl/Fgfr3^tm2Schl (Fgfr3c^-/-) mice relative to wild-type (WT) controls. (B) Representative three-dimensional images of trabecular bone just below the growth plate of WT (left), Fgfr3^tm1Schl/Fgfr3^tm1Schl (Fgfr3b^-/-, center), and Fgfr3^tm2Schl/Fgfr3^tm2Schl, (right) mice. Note the thinning of the trabecular boen and the increase in the trabecualr space of Fgfr3^tm2Schl/Fgfr3^tm2Schl mice relative to wild-type controls.

Copyright

This image is from Eswarakumar VP, Proc Natl Acad Sci U S A 2007 Mar 6;104(10):3937-42. Copyright 2007 National Academy of Sciences, U.S.A. J:142946

Associated Alleles

Symbol	Name
Fgfr3^tm1Schl	fibroblast growth factor receptor 3; targeted mutation 1, Joseph Schlessinger
Fgfr3^tm2Schl	fibroblast growth factor receptor 3; targeted mutation 2, Joseph Schlessinger