Phenotype Image Detail

Image

Caption

(A) Wild-type (left), Cstf2t^tm1Ccma/Cstf2t⁺ (center) Cstf2t^tm1Ccma/Cstf2t^tm1Ccma (right) mice are indistinguishable by body size, behavior, or other overt characteristics (note that coat color is arbitrary and not distinguishing in these mice). (B) Gross anatomy and weights of reproductive organs are indistinguishable between wild-type (left), heterozygotes (center) and mutants (right). E, epididymis; T, testis; V, vas deferens; B, bladder; SV/CG, seminal vesicle and coagulating gland. (C and D) Cauda epididymal sperm from wild-type (C) and mutant (B) mice. Arrows indicate round cells (probably prematurely released round spermatids); arrowheads indicate spermatozoa with abnormal head morphology.

Copyright

This image is from Dass B, Proc Natl Acad Sci U S A 2007 Dec 18;104(51):20374-9. Copyright 2007 National Academy of Sciences, U.S.A. J:130584

Associated Alleles

Symbol	Name
Cstf2t^tm1Ccma	cleavage stimulation factor, 3' pre-RNA subunit 2, tau; targeted mutation 1, Clinton C MacDonald

Associated Genotypes

Allelic Composition	Genetic Background
Cstf2t^tm1Ccma/Cstf2t^tm1Ccma	involves: 129S/SvEv * C57BL/6