Phenotype Image Detail

Image

Caption

Postnatal survival and appearance of Gucy1b1^tm1.1Frb/Gucy1b1^tm1.1Frb mice. (A) Postnatal survival of wild-type (WT), heterozygous, and Gucy1b1^tm1.1Frb/Gucy1b1^tm1.1Frb (GC-KO) mice. WT (n=243) and heterozygous (Beta1^-/+; n=483) mice were observed for ~4 weeks. The survival of homozygous mutant mice (n=126) was monitored until death. Feeding with fiber-free diet improved the survival of homozygous mutant mice (Gucy1b1^tm1.1Frb/Gucy1b1^tm1.1Frb+diet; n=58). (B) WT and homozygous mutant siblings at ~21 days of age. Body weight (BW) ratio of wild-type (100%; n=24) and homozygous mutant (n=28) mice are shown (right). Three-week old siblings of the same sex were compared for BW determination.

Copyright

This image is from Friebe A, Proc Natl Acad Sci U S A 2007 May 1;104(18):7699-704. Copyright 2007 National Academy of Sciences, U.S.A. J:121321

Associated Alleles

Symbol	Name
Gucy1b1^tm1.1Frb	guanylate cyclase 1, soluble, beta 1; targeted mutation 1.1, Andreas Friebe

Associated Genotypes

Allelic Composition	Genetic Background
Gucy1b1^tm1.1Frb/Gucy1b1^tm1.1Frb	involves: 129 * C57BL/6 * FVB/N