Phenotype Image Detail

Image

Caption

Aqp2^cph/Aqp2^cph mutants have apparent congenitial obstruction at multiple levels. (A) At two weeks of age, Aqp2^cph/Aqp2^cph (mutant) mice are significantly smaller than wild-type (control) littermates. Scale bar: 1 cm. (B) The mutants grow slower than the controls. Triangle, controls; square, mutants. (C-E) The mutants have unilateral or bilateral hydronephrosis and hydroureter (arrow). (F) The blood urea nitrogen (BUN) level in the mutants (P5-P16) is 70.0 +/- 25.0 mg/dl (n=35), significantly (P <0.001) higher than that of the controls (P5-P16, 26.8 +/- 5.0 mg/dl; n = 29). (G and H) Kidney sections from P14 control and mutant littermates stained with hematoxylin and eosin.

Copyright

This image is from McDill BW, Proc Natl Acad Sci U S A 2006 May 2;103(18):6952-7. Copyright 2006 National Academy of Sciences, U.S.A. J:109463

Associated Alleles

Symbol	Name
Aqp2^cph	aquaporin 2; congenital progressive hydronephrosis

Associated Genotypes

Allelic Composition	Genetic Background
Aqp2^cph/Aqp2^cph	C57BL/6J-Aqp2^cph