Phenotype Image Detail

Image

Caption

Gross and pathologic anatomy of disseminated S. xylosus infection in Ncf1^tm1Shl/Ncf1^tm1Shl mice. (A) An abscess of the left hindpaw (arrow) of a 15 week old Ncf1^tm1Shl/Ncf1^tm1Shl female mouse. This mouse also had cutaneous abscesses of the right periauricular soft tissue and the right forepaw. The lesions were fluctuant and grew S. xylosus in culture. (B) Necropsyy of the mouse shown in A. A 5-mm pyogranuloma of the right caudal lobe of the lung is indicated (arrow). (C) Multinucleated giant cells were found throughout the inflammatory lung tissue indicated in B. Characteristic granulomatous inflammation was found interspersed with acute inflammation (hematoxylin and eosin stain, x630).

Copyright

This image is from Jackson SH, J Exp Med 1995 Sep 1;182(3):751-8, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:28267

Associated Alleles

Symbol	Name
Ncf1^tm1Shl	neutrophil cytosolic factor 1; targeted mutation 1, Steven M Holland

Associated Genotypes

Allelic Composition	Genetic Background
Ncf1^tm1Shl/Ncf1^tm1Shl	involves: 129S2/SvPas * C57BL/6J