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Caption | (A) Sections of 3 week-old wild-type (+/+, a,c,e and g) and Nfkb2tm1Brv/Nfkb2tm1Brv (-/-, b,d,f and h) spleen (a and b) thymus (c and d), lymph node (e and f) and bone marrow (g and h) stained with hematoxylin and eosin (original magnification: a,b,e and f, 12.5-fold; c and d, 5-fold; g and h, 375-fold). Both spleen (b) and thymus (d) of mutant mice were atrophic, showing poorly demarcated white (WP, arrows) and red pulp, and cortico-medullary junctions, respectively. (f) Lymph nodes were clearly enlarged and lymphatic follicle (LF, arrows) was not well defined in mutant mice. (h) Granulocyte percursors and neutrophils (arrows) markedly accumulated in mutant bone marrow. WP, white pulp; RP, red pulp; Co, cortex; Me, medulla; LF, lymphatic follicle; PA, paracortical area. | ||||
Copyright | This image is from Ishikawa H, J Exp Med 1997 Oct 6;186(7):999-1014, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:43469 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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