Phenotype Image Detail

Image

Caption

(A) Sections of 3 week-old wild-type (+/+, a,c,e and g) and Nfkb2^tm1Brv/Nfkb2^tm1Brv (-/-, b,d,f and h) spleen (a and b) thymus (c and d), lymph node (e and f) and bone marrow (g and h) stained with hematoxylin and eosin (original magnification: a,b,e and f, 12.5-fold; c and d, 5-fold; g and h, 375-fold). Both spleen (b) and thymus (d) of mutant mice were atrophic, showing poorly demarcated white (WP, arrows) and red pulp, and cortico-medullary junctions, respectively. (f) Lymph nodes were clearly enlarged and lymphatic follicle (LF, arrows) was not well defined in mutant mice. (h) Granulocyte percursors and neutrophils (arrows) markedly accumulated in mutant bone marrow. WP, white pulp; RP, red pulp; Co, cortex; Me, medulla; LF, lymphatic follicle; PA, paracortical area.

Copyright

This image is from Ishikawa H, J Exp Med 1997 Oct 6;186(7):999-1014, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:43469

Associated Alleles

Symbol	Name
Nfkb2^tm1Brv	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 1, Rodrigo Bravo

Associated Genotypes

Allelic Composition	Genetic Background
Nfkb2^tm1Brv/Nfkb2^tm1Brv	involves: 129S1/Sv * C57BL/6