Phenotype Image Detail

Image

Caption

Irf6^clft1/Irf6^clft1 palatal defects. (a-c) E18.5 whole mount preparations with mandible and tongue removed. Irf6^clft1/Irf6^clft1 (clft1) mutants (b,c) show posterior cleft secondary palate, with normal elevation and fusion anteriorly (b), or complete cleft secondary palate (c). Arrowhead in b indicates closure of anterior palate. (d-k) Histological analysis at E16.5. Coronal sections from posterior, middle, and anterior portion of the oral cavity as indicated (*, palatal tissue; tg, tongue). (j,k) Higher magnification view of the oral adhesions between tongue and palate seen in mutants.

Copyright

This image is from Stottmann RW, Genesis 2010 May;48(5):303-8, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:160190

Associated Alleles

Symbol	Name
Irf6^clft1	interferon regulatory factor 6; cleft palate 1

Associated Genotypes

Allelic Composition	Genetic Background
Irf6^clft1/Irf6^clft1	involves: A/J * FVB