Phenotype Image Detail

Image

Caption

Compared with wild-type (WT) embryos, Gata5^tm1Eem/Gata5^tm1Eem (Gata5^-/-) and Gata4^tm1Jml/Gata4⁺ (Gata4^+/-) (1st to 3rd rows, respectively) mice appeared grossly normal, whereas Gata4^tm1Jml/Gata4⁺ Gata5^tm1Eem/ Gata5^tm1Eem (5th row) compound mutants all died mid-gestation with no survivors past E14.5. There was progressive ventricular wall thinning, and the compact myocardium was hypoplastic with increasingly fine, abnormal trabecular structures with loss of each additional Gata5 allele in the setting of Gata4 heterozygosity (3rd to 5th rows).

Copyright

This image is from Singh MK, J Biol Chem 2010 Jan 15;285(3):1765-72 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:155855

Associated Alleles

Symbol	Name
Gata4^tm1Jml	GATA binding protein 4; targeted mutation 1, Jeffrey M Leiden
Gata5^tm1Eem	GATA binding protein 5; targeted mutation 1, Edward E Morrisey

Associated Genotypes

Allelic Composition	Genetic Background
Gata4^tm1Jml/Gata4^+ Gata5^tm1Eem/Gata5^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Gata4^tm1Jml/Gata4^+ Gata5^tm1Eem/Gata5^tm1Eem	involves: 129S1/Sv * 129X1/SvJ * C57BL/6