Phenotype Image Detail

Image

Caption

Conotruncal and endocardial cushion phenotype of E14.5 Gata4^tm1Jml/Gata4⁺ Gata5^tm1Eem/Gata5^tm1Eem mice. Gata4^tm1Jml/Gata4⁺ Gata5^tm1Eem/Gata5^tm1Eem (Gata4^-/+/Gata5^-/-) mutant mice harbored multiple defects in distinct anatomic compartments. Gata5^tm1Eem/Gata5⁺ mice appeared normal with no identifiable intracardiac defects (A-C and G). Gata4^tm1Jml/Gata4⁺ Gata5^tm1Eem/Gata5⁺ double heterozygotes were viable but demonstrated conoventricular septal defects with incomplete penetrance (H, arrow). Gata4^tm1Jml/Gata4⁺ Gata5^tm1Eem/Gata5^tm1Eem compound mutants demonstrated moderately hypoplastic and anteriorly malaligned left ventricular outflow tracts (D-F). Similarly, ventriculoarterial positioning of the right ventricular outflow tract was more posteriorly positioned than normal (K-M). There was hypoplasia of the endocardial cushions leading to complete common atrioventricular canal defects. This was associated with a primum atrial septal defect as well as a large ventricular septal defect modeling human complete common atrioventricular canal (I and J).

Copyright

This image is from Singh MK, J Biol Chem 2010 Jan 15;285(3):1765-72 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:155855

Associated Alleles

Symbol	Name
Gata4^tm1Jml	GATA binding protein 4; targeted mutation 1, Jeffrey M Leiden
Gata5^tm1Eem	GATA binding protein 5; targeted mutation 1, Edward E Morrisey

Associated Genotypes

Allelic Composition	Genetic Background
Gata4^tm1Jml/Gata4^+ Gata5^tm1Eem/Gata5^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Gata4^tm1Jml/Gata4^+ Gata5^tm1Eem/Gata5^tm1Eem	involves: 129S1/Sv * 129X1/SvJ * C57BL/6