Phenotype Image Detail

Image

Caption

The peripheral inner nuclear layer cell loss peaks at 9 months of age and is associated with reduced electroretinogram (ERG) responses in Lama1^nmf223/Lama1^nmf223 mice as shown by a summary of strobe flash ERG results obtained at 1 year of age. Resembling littermate controls (wild-type, A), H/E staining reveals a normal central retina in 9-month old Lama1^nmf223/Lama1^nmf223 mice (B). However, compared with littermate controls (C), the peripheral inner nuclear layer is thinner in mutants (D). The following abbreviations represent the retinal layers: ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL). E: Dark-adapted responses obtained from a representative wild-type (WT, left) and mutant (right) mouse. Scale bar, 100 ms and 500 uV. F: Intensity-response functions for the dark-adapted a- and b- wave of WT and mutants. G: Cone ERGs obtained from a representative WT (left) and mutant (right) mouse. Scale bar 100 ms and 100 uV. H: Intensity response functions for the cone ERG b-wave of WT and mutants. In E and G, the numbers to the left of each pair of waveforms indicate flash intensity (in log cd s/m², and the dashed lines indicate the time of flash presentation. In F and H, data points indicate the average for four WT and six mutants. Error bars, +/- S.E.

Copyright

This image is from Edwards MM, J Biol Chem 2010 Mar 5;285(10):7697-711 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:160722

Associated Alleles

Symbol	Name
Lama1^nmf223	laminin, alpha 1; neuroscience mutagenesis facility, 223

Associated Genotypes

Allelic Composition	Genetic Background
Lama1^nmf223/Lama1^nmf223	C57BL/6J-Lama1^nmf223/J