Phenotype Image Detail

Image

Caption

Fundus photographs of 8 week-old littermate controls (Lama1^delta/+, A) and Lama1^tm1Olf/Lama1^tm1Olf Edil3^{Tg(Sox2-cre)1Amc}/0 mutants (Lama1^delta/delta, B) reveal white retinal spots (arrows) as well as vitreal fibroplasia (asterisk) in the mutant retina. ADPase staining of 6 month-old mice highlights normal retinal vasculature in heterozygous control mice (C), whereas vessels in the homozygous mutant mice are tortuous, with larger vessels lying in the vitreous (D). GFAP and G. simplicifolia isolectin (GS isolectin) staining demonstrates the normal retinal vasculature and astrocyte template in littermate controls (E) compared with the association of astrocytes with vitreal vessels in homozygous mutants (F).

Copyright

This image is from Edwards MM, J Biol Chem 2010 Mar 5;285(10):7697-711 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:160722

Associated Alleles

Symbol	Name
Edil3^Tg(Sox2-cre)1Amc	EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Lama1^tm1Olf	laminin, alpha 1; targeted mutation 1, Olivier Lefebvre

Associated Genotypes

Allelic Composition	Genetic Background
Lama1^tm1Olf/Lama1^tm1Olf Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster