Phenotype Image Detail

Image

Caption

Peripheral retinal degeneration is observed in Lama1^tm1Olf/Lama1^tm1Olf Edil3^{Tg(Sox2-cre)1Amc}/0 mice as early as 4 weeks of age. H&E staining demonstrates that the central retina of Lama1^tm1Olf/Lama1^tm1Olf Edil3^{Tg(Sox2-cre)1Amc}/0 mice (Lama1^delta) is similar to that of littermate controls (A) at both 4 weeks (B) and 6 months (C) with the exception of the inner limiting membrane defects. The peripheral retina, however, shows thinning of the outer and inner nuclear layers as well as a loss of ganglion cell layer cells in 4 week-old mutants (E) compared with controls (D). This thinning progresses slightly and affects the outer nuclear and inner plexiform layers as well in retinas of 6 month-old mutants (F). GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer. G: Intensity response functions for the dark-adapted a- and b-waves of mutant mice (open circle) compared with control mice at 1 year of age (filled circle). H: Intensity-related functions for the cone ERG b-wave of 1 year-old mutants compared with control littermates. In G and H, error bars indicate S.E.

Copyright

This image is from Edwards MM, J Biol Chem 2010 Mar 5;285(10):7697-711 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:160722

Associated Alleles

Symbol	Name
Edil3^Tg(Sox2-cre)1Amc	EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Lama1^tm1Olf	laminin, alpha 1; targeted mutation 1, Olivier Lefebvre

Associated Genotypes

Allelic Composition	Genetic Background
Lama1^tm1Olf/Lama1^tm1Olf Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster