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Caption | Peripheral retinal degeneration is observed in Lama1tm1Olf/Lama1tm1Olf Edil3Tg(Sox2-cre)1Amc/0 mice as early as 4 weeks of age. H&E staining demonstrates that the central retina of Lama1tm1Olf/Lama1tm1Olf Edil3Tg(Sox2-cre)1Amc/0 mice (Lama1delta) is similar to that of littermate controls (A) at both 4 weeks (B) and 6 months (C) with the exception of the inner limiting membrane defects. The peripheral retina, however, shows thinning of the outer and inner nuclear layers as well as a loss of ganglion cell layer cells in 4 week-old mutants (E) compared with controls (D). This thinning progresses slightly and affects the outer nuclear and inner plexiform layers as well in retinas of 6 month-old mutants (F). GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer. G: Intensity response functions for the dark-adapted a- and b-waves of mutant mice (open circle) compared with control mice at 1 year of age (filled circle). H: Intensity-related functions for the cone ERG b-wave of 1 year-old mutants compared with control littermates. In G and H, error bars indicate S.E. | ||||||
Copyright | This image is from Edwards MM, J Biol Chem 2010 Mar 5;285(10):7697-711 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:160722 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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