Phenotype Image Detail

Image

Caption

Skeleton preparations of E18 P3h1^tm1Dgen/P3h1^tm1Dgen mice. Skeletons of E18 P3h1^tm1Dgen/P3h1^tm1Dgen mice were stained with alizarin red and Alcian blue to detect differences in mineralized bone and cartilage, respectively (A and B). The primary difference detected at this developmental stage is the lack of ossification in the parietal bone in the skull of homozygous mutant mice (B) as compared with heterozygous mice (A) indicating a delay in ossification in the homozygous mice. (Note: bone mineral density in heterozygous mice was indistinguishable from that of wild-type mice.

Copyright

This image is from Vranka JA, J Biol Chem 2010 May 28;285(22):17253-62 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:163884

Associated Alleles

Symbol	Name
P3h1^tm1Dgen	prolyl 3-hydroxylase 1; targeted mutation 1, Deltagen

Associated Genotypes

Allelic Composition	Genetic Background
P3h1^tm1Dgen/P3h1^tm1Dgen	involves: C57BL/6