Phenotype Image Detail

Image

Caption

Skin of P3h1^tm1Dgen/P3h1^tm1Dgen mice. Electron microscope images of adult wild-type (+/+, A and C) and P3h1^tm1Dgen/P3h1^tm1Dgen mouse skin (-/-, B and D) were analyzed and show abnormalities in the reticular dermis of the mutant skin collagen fibrils where many irregular, fused collagen fibrils are found (arrows in B), as well as more spaces between fibril bundles (D) as compared with wild-type skin (scale bar = 2 um). Cryosections of adult skin were also stained with Masson trichrome stain to detect collagen fibrils in wild-type (E) and mutant (F) dermis (scale bar = 120 um). Mutant skin was overall thinner and slightly less dense than the wild-type skin.

Copyright

This image is from Vranka JA, J Biol Chem 2010 May 28;285(22):17253-62 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:163884

Associated Alleles

Symbol	Name
P3h1^tm1Dgen	prolyl 3-hydroxylase 1; targeted mutation 1, Deltagen

Associated Genotypes

Allelic Composition	Genetic Background
P3h1^tm1Dgen/P3h1^tm1Dgen	involves: C57BL/6