Phenotype Image Detail

Image

Caption

A, video clips of wild-type (wt) and Canx^{Gt(KST286)Byg}/Canx^{Gt(KST286)Byg} (cnx-/-) sibling mice. The full-length video is available as supplemental material. Mutant mice are smaller than their wild-type counterparts, with splaying of the hind limbs and gait instability. B, Mutant and wild-type brains isolated from 21-day-old mice, viewed from the dorsal and ventral side. There were no morphological differences in the anatomical structure between mutant and wild-type brains as examined in multiple animals. C, analysis of motor neuron number in wild-type and mutant mice. The spinal cord length is shorter in mutant mice, but the spinal motoneuron distribution and number were similar to that in wild-type mice. In red are the neurons counted on the left side of the spinal cord; in green are the neurons counted on the right side of the spinal cord. Motoneurons were counted in two sets of wild-type and mutant mice. D, sympathetic neurons from day 1 neonate mutant and wild-type mice were grown in compartmentalized cultures (Campenot cultures). Axonal growth was examined in three sets of wild-type and mutant cultures. The absence of calnexin had no effect on axonal growth.

Copyright

This image is from Kraus A, J Biol Chem 2010 Jun 11;285(24):18928-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:164553

Associated Alleles

Symbol	Name
Canx^Gt(KST286)Byg	calnexin; gene trap KST286, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Canx^Gt(KST286)Byg/Canx^Gt(KST286)Byg	involves: 129P2/OlaHsd * C57BL/6