Phenotype Image Detail

Image

Caption

Electron micrographs demonstrate dysmyelination. Representative electron microscopy micrographs shown here depict spinal cords and sciatic nerves from 21-day old mice, although dysmyelination was observed in mice from 3 weeks to 2 years of age. Four sets of 21-day-old sex-matched mice were examined, using either tissue fixation by immersion or perfusion. Areas of wavy, decompacted myelin and hypomyelination appear in anterior (A and B) and posterior (C and D) regions of the spinal cord of Canx^{Gt(KST286)Byg}/Canx^{Gt(KST286)Byg} (cnx-/-) mutant mice. The black arrows indicate areas of myelin shown magnified in the insets. Myelin abnormalities also appeared in the sciatic nerve (E and G). Redundant myelin folds are noted. F and H are higher magnifications of the regions indicated by black arrows in E and G, respectively. The white arrows indicate the areas of wavy myelination (B), hypomyelination (D), and aberrant myelination (G). A-D, scale bar, 5 um; inset, scale bar, 500 nm; E and G, scale bar, 2 um; F and H, scale bar, 200 nm.

Copyright

This image is from Kraus A, J Biol Chem 2010 Jun 11;285(24):18928-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:164553

Associated Alleles

Symbol	Name
Canx^Gt(KST286)Byg	calnexin; gene trap KST286, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Canx^Gt(KST286)Byg/Canx^Gt(KST286)Byg	involves: 129P2/OlaHsd * C57BL/6