Phenotype Image Detail

Image

Caption

A, macroscopic appearance of antral mucosal thickening and frequency of antral hyperplasia in Spdef^tm1Shiv/Spdef^tm1Shiv (Spdef^-/-) mice; scale bar 5 mm. Fo, forestomach; Co, corpus; An, antrum; Du, duodenum. B-E, as compared with normal wild-type antra (B), histology of the lesions reveals elongated, tortuous foveolae (C) with expanded proliferative zones (D, Ki67 staining) and separation of glands by smooth muscle actin (Sma)-expressing connective tissue bands (E, arrow). Foveolar pit cell differentiation is preserved, as indicated by apical Muc5ac staining (E, arrows). Insets show higher magnifications of the boxed areas. Scale bars, B, 100 um; C-E, 250 um.

Copyright

This image is from Horst D, J Biol Chem 2010 Nov 5;285(45):35047-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166876

Associated Alleles

Symbol	Name
Spdef^tm1Shiv	SAM pointed domain containing ets transcription factor; targeted mutation 1, Ramesh Shivdasani

Associated Genotypes

Allelic Composition	Genetic Background
Spdef^tm1Shiv/Spdef^tm1Shiv	involves: 129S4/SvJae