Phenotype Image Detail

Image

Caption

Spermatogenic disruption in the testes of Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc mice. A-D, wild-type testes display robust spermatogenesis (A), whereas Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc (Zmynd15^-/-) testes showed severe spermatid depletion characterized by spermatid clusters that are detaching from the seminiferous epithelium followed by sloughing into the lumen of the seminiferous tubules (arrows in B-D). The Roman numerals indicate stages of the seminiferous epithelial cycles. A-D are in the same magnification. Scale bar, 20 um. E and F, TUNEL analyses of cell apoptosis showed very few apoptotic germ cells in wild-type testes (E), whereas in mutant testes many TUNEL-positive germ cells resembling mainly round spermatids and spermatocytes are present (F). E and F are in the same magnification. Scale bar, 20 um.

Copyright

This image is from Yan W, J Biol Chem 2010 Oct 8;285(41):31418-26 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166802

Associated Alleles

Symbol	Name
Del(11Cxcl16-Zmynd15)1Ifc	deletion, Chr 11, Israel F Charo

Associated Genotypes

Allelic Composition	Genetic Background
Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc	involves: 129S4/SvJae * C57BL/6