Phenotype Image Detail

Image

Caption

In histological sections of eyes from 8 day-old BALB/cJ (I,M) and ICR mice (J,N), no pathological changes are observed. In contrast polygon epithelial cells in anterior lens capsule are seen in Crygc^M1Sbao/Crygc^M1Sbao mice. Sponge-like degeneration is seen in the cortical area underneath the anterior lens capsule in mutant mice. Epithelial cells overproliferate and become polygon in shape in the equatorial region in mutant mice, and sponge-like and vacuole-like degeneration in the cortical area under the posterior lens capsule is seen heterozygous and homozygous mutant mice (arrow), respectively. Pink-stained embryonic nucleus of the lens and the fibers become swollen and lose the normal arrangement in the nucleus (arrow). K,L: Posterior lens capsule from heterozygous and homozygous mice. O,P: Nucleus of the lens from heterozygous and homozygous mice. Magnification: x400.

Copyright

This image is from Zhao L, Mamm Genome 2010 Aug;21(7-8):361-9 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:163241

Associated Alleles

Symbol	Name
Crygc^M1Sbao	crystallin, gamma C; mutation 1, Shimin Bao

Associated Genotypes

Allelic Composition	Genetic Background
Crygc^M1Sbao/Crygc^M1Sbao	involves: BALB/cJ * ICR
Crygc^M1Sbao/Crygc^+	involves: BALB/cJ * ICR