Phenotype Image Detail

Image

Caption

(A) Representative figures of a terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Increase of TUNEL-positive apoptotic cells (red) in the Prkdc^tm1.1Bpcc/ Prkdc^tm1.1Bpcc (DNA-PKcs^3A/3A) intestinal crypt (outlined with dashed lines). Nuclei were counterstained with DAPI (blue). Bar, 50 um. (B) Skin hyperpigmentation is clearly distinguishable in the mutant footpad and tail. (C) Hematoxylin and eosin staining of tail skin section. Massive melanin accumulated in the mutant epidermis and was abolished in a p53-null background. Bar, 20 um.

Copyright

This image is from Zhang S, J Cell Biol 2011 Apr 18;193(2):295-305, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:171351

Associated Alleles

Symbol	Name
Prkdc^tm1.1Bpcc	protein kinase, DNA activated, catalytic polypeptide; targeted mutation 1.1, Benjamin P C Chen