Phenotype Image Detail

Image

Caption

(A) Gross appearance of E13.5 wild-type (+/+), Sos1^tm1.2Rak/Sos1⁺ (+/EK), and Sos1^tm1.2Rak/Sos1^tm1.2Rak (Sos1^EK/EK) embryos. (B) Representative Hematoxylin & Eosin (H&E) stained transverse sections of hearts from E15.5 wild-type, heterozygous, and homozygous mutant embryos. Note edema (asterisks), atrial septum (AS, red arrowhead), atrial septal defect (ASD, cyan arrows), ventricular septal defect (VSD, blue arrowhead), right ventricular hypertrophy (open circle), and interventricular septum (IVS) hypertrophy (open triangle) in homozygous mutant hearts. PV, pulmonary valve. PV and AV original magnification, x10. Four-Chamber sections original magnification, x4.

Copyright

This image is from Chen PC, J Clin Invest 2010 Dec 1;120(12):4353-65 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171873

Associated Alleles

Symbol	Name
Sos1^tm1.2Rak	SOS Ras/Rac guanine nucleotide exchange factor 1; targeted mutation 1.2, Raju Kucherlapati

Associated Genotypes

Allelic Composition	Genetic Background
Sos1^tm1.2Rak/Sos1^tm1.2Rak	involves: 129S/Sv * C57BL/6 * FVB/N * SJL
Sos1^tm1.2Rak/Sos1^+	involves: 129S/Sv * C57BL/6 * FVB/N * SJL