Phenotype Image Detail

Image

Caption

The muscle weakness phenotype of Fbn2^mz/Fbn2^mz mice. The original pedigree in which the Fbn2^mz/Fbn2^mz (Mz/Mz) mutant was identified. (B) Grip-strength comparison using 3-month old mutants (n=30) and wild-type (+/+) (n=26) littermates. The average force generated by wild-type mice has been set as 100%. Mean and SD are shown. The differences are highly significant; P-values (Student's test): *** P<0.0001. (C) Close-up photos showing the different grasp of mutants and wild-type littermates. (D) Example of clasping phenotype observed in mutants and wild-type littermates. (E) A wire manoeuvre test of mutant and wild-type littermates. Scores as as follows: 0 = mouse swings hindlegs on to bar and makes way to edge rapidly; 1 = mouse swing hindlegs on to bar after a delay and makes way to edge rapidly; 2 = mouse is suspended by using underarms to straddle bar and does not lift hind limbs, eventually falls; 3 = mouse falls after short delay; 4 = mouse fall immediately.

Copyright

This image is from Miller G, PLoS One 2010;5(2):e9137, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:157998

Associated Alleles

Symbol	Name
Fbn2^mz	fibrillin 2; mariusz

Associated Genotypes

Allelic Composition	Genetic Background
Fbn2^mz/Fbn2^mz	involves: BALB/cAnNCrl * C3H/HeH