Phenotype Image Detail

Image

Caption

(A) Examples of different fusion phenotypes observed - four toes (#1), four toes with two toes fused (#2), four toes with skewed digit (#3), misture of two digit phenotypes in a single mouse (#4). (B) Hard and soft tissue fusion seen in Fbn2^mz/Fbn2^mz (Mz/Mz) mice. Alcian Blue/Alizarin Red-stained left hindlimbs of P7 mice showing a littermate Fbn2^mz/Fbn2⁺ (Mz/+, left), soft tissue syndactyly of toes 3 and 4 (center), and syndactyly of toes 2,3 and 4 with fusion of the distal phalanges (right). (C) X-ray analysis of a hindlimb of a mutant demonstrating fusion of the soft tissue as well as the distal phalanx bones. (D) Morag test on mutant mice and wild-type littermates. The proportion of trails in which the mice were able to grasp the food pellets and retreive the pellets to their mouths are shown. (E) Mutant mice have a reduced body weight. Growth curves of mutant male mice and littermate controls. Picture shows a typical example of the size difference between an adult mutant female mouse and littermate control at 3 months of age.

Copyright

This image is from Miller G, PLoS One 2010;5(2):e9137, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:157998

Associated Alleles

Symbol	Name
Fbn2^mz	fibrillin 2; mariusz

Associated Genotypes

Allelic Composition	Genetic Background
Fbn2^mz/Fbn2^mz	involves: BALB/cAnNCrl * C3H/HeH