Phenotype Image Detail

Image

Caption

Light-microscopic histological examination is conducted to evaluate retinal neuropathy in Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat (Vav2^-/- Vav3^-/-) mice. A. At the age of 3 weeks, mutant mice exhibited impairment of angle status, but no abnormal findings of Optic nerve head degeneration (ONH) or retinal ganglion cells (RGCs) in the retinas. Scale bars, from left to right side: 500 um, 100 um, and 50 um. B. After evaluation of intraocular pressure (IOP), compared to control wild-type (WT) mice in the upper panel, ONH in 10-, 15-, and 30-week old mutant mice present so-called capping (shown in c) and thin retinal neural layers (indicated by arrows in the photos). In those retinas, RGCs are decreased. Scale bars, from left to right side: 500 um, 100 um and 50 um. Sections are representative from 6-12 samples.

Copyright

This image is from Fujikawa K, PLoS One 2010;5(2):e9050, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158008

Associated Alleles

Symbol	Name
Vav2^tm1Kdf	vav 2 oncogene; targeted mutation 1, Klaus-Dieter Fischer
Vav3^tm1Swat	vav 3 oncogene; targeted mutation 1, Wojciech Swat

Associated Genotypes

Allelic Composition	Genetic Background
Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat	B6.129S-Vav2^tm1Kdf Vav3^tm1Swat