Phenotype Image Detail

Image

Caption

(a-c) Gross morphology, (d-e) H&E histology of control mice not treated with GW501516 (GW; d), or fourteen days after induction (e-g). Magnification 200x (d,e) or 400x (f). The white arrowhead in (f) denotes the granular layer. (g) Immunostaining for Ki67 of skin from Tg(CYP1A1-PPARD)#Jfoe/0 mice maintained in the absence (left) or presence (right) of GW. Magnification 200x. (h) Induction of skin disease by topical application of either 0.3% of indole-3-carbinole (I3C, left) or I3C plus 0.3% GW501516 once daily to shaved abdominal skin. Gross macroscopic phenotype (top) and H&E histology of treated skin (bottom) was documented 10 days after beginning treatment.

Copyright

This image is from Romanowska M, PLoS One 2010;5(3):e9701, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158907

Associated Alleles

Symbol	Name
Tg(CYP1A1-PPARD)#Jfoe	transgene insertion, John Foerster

Associated Genotypes

Allelic Composition	Genetic Background
Tg(CYP1A1-PPARD)#Jfoe/0	involves: C57BL/6J * CBA