Phenotype Image Detail

Image

Caption

Histologic sections of wild-type (Pax2^+/+) and Pax2^M1Bpb/Pax2^M1Bpb (Pax2^A220G/A220G) mouse eyes at three embryonic time points. At E11.5, parasagittal sections reveal a delay in apposition of the edges of the optic fissure in Pax2^M1Bpb/Pax2^M1Bpb mice (arrow, A,B). At E13.5, coronal sections through the wild-type and mutant embryos reveal a delay in the formation of the tunica vasculosis lentis (arrow, C,D). At E17.5, parasagittal sections demonstrate non-fusion of the optic fissure (uveal coloboma) in mutant embryos (arrow, E,F). V, ventral retina.

Copyright

This image is from Alur RP, PLoS Genet 2010;6(3):e1000870, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:159240

Associated Alleles

Symbol	Name
Pax2^M1Bpb	paired box 2; mutation 1, Brian P Brooks

Associated Genotypes

Allelic Composition	Genetic Background
Pax2^M1Bpb/Pax2^M1Bpb	C57BL/6-Pax2^M1Bpb