Phenotype Image Detail

Image

Caption

(A) A 13-week old Dnm1l^Py/Dnm1l⁺ (Py/+) mouse compared to a wild-type littermate control (+/+). (B) Kaplan-Meier analysis of onset of overt congestive heart failure (CHF) in mutant mice on the C3H/HeN and C57BL/6J genetic backgrounds compared to wild-type littermate. (C) Photo of the excised hearts from a 13-week old mutant and wild-type mouse. Note the grossly enlarged ventricles and atria. (D) H&E section through a wild-type and mutant heart showing clinical signs of CHF. Note the distended ventricles; R = right, L = Left. (E) Oedematous dermal connective tissue evident in a H&E stained section from a mutant mouse showing clinical signs of CHF compared to a littermate control. (F) MSB staining of heart sections of mutant mice showing clinical signs of CHF. Note enlarged cardiomyocytes (indicated by a red bracket) and increased collagen deposition (indicated by black bracket). (G) Morphometric analysis of MSB-stained section demonstrating the level of increase in collagen deposition. Data shown is % of image area (mean +/- SEM) that is taken up by collagen deposition from 3 mutants showing overt signs of CHF and 3 wild-type age-matched males. Five images were taken per sample. (H) Evidence of cardiac calcification in a Von Kossa-stained section of a mutant heart.

Copyright

This image is from Ashrafian H, PLoS Genet 2010;6(6):e1001000, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:161510

Associated Alleles

Symbol	Name
Dnm1l^Py	dynamin 1-like; Python

Associated Genotypes

Allelic Composition	Genetic Background
Dnm1l^Py/Dnm1l^+	involves: BALB/cAnNCrl * C3H/HeH
Dnm1l^Py/Dnm1l^+	involves: BALB/cAnNCrl * C3H/HeH * C57BL/6J