Phenotype Image Detail

Image

Caption

(A, A') Lateral view of whole wild-type (wt/wt) and Vcl^tm1.1Whz/Vcl^tm1.1Whz (ki/ki) embryos at E10.5. In the mutant embryo (A'), exencephaly resulting from a neural tube closure defect is shown (arrow heads). (B, B') Hematoxylin & Eosin staining of sagittal sections from wild-type and mutant embryos at E10.5. m, mesencephalon; t, telencephalon; h, heart; sc, spinal cord; drg, dorsal root ganglia; cg, cranial ganglia; bv, blood vessels. Corresponding nuclear (C, C') and TUNEL (D, D') staining in wild-type and mutant embryos at E10.5. Note increased cell death in mutant embryos (arrows). Scale bars: 500 um.

Copyright

This image is from Marg S, PLoS One 2010;5(7):e11530, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:163108

Associated Alleles

Symbol	Name
Vcl^tm1.1Whz	vinculin; targeted mutation 1.1, Wolfgang H Ziegler

Associated Genotypes

Allelic Composition	Genetic Background
Vcl^tm1.1Whz/Vcl^tm1.1Whz	involves: 129/Sv * C57BL/6 * SJL