Phenotype Image Detail

Image

Caption

Testes and ovaries from wild-type (Rpn13^+/+) and Adrm1^{Gt(OST128063)Lex}/Adrm1^{Gt(OST128063)Lex} (Rpn13^-/-) mice at 3 and 12 weeks of age were subjected to H&E staining. Arrows point to the following features: 1. Maturing sperm in the tubular lumen of wild-type testis which are absent in the mutant section, and Leydig cell clusters present in both sections of 12 week old mice; 2. Spermatids and spermatogonia in the wild-type testis are largely missing from mutant mice, and hypertrophic Sertoli cells in the mutant testes of 3 week old mice; 3. Primordial follicles with ova and granulose cells present only in the wild-type ovary, and are replaced by interstitial stroma in mutant ovary of 12 week old mice; 4. Ova are numerous in wild-type and few in mutant mice at 3 weeks of age.

Copyright

This image is from Al-Shami A, PLoS One 2010;5(10):e13654, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:166694

Associated Alleles

Symbol	Name
Adrm1^Gt(OST128063)Lex	adhesion regulating molecule 1 26S proteasome ubiquitin receptor; gene trap OST128063, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Adrm1^Gt(OST128063)Lex/Adrm1^Gt(OST128063)Lex	involves: 129S5/SvEvBrd * C57BL/6J