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Phenotype Image Detail
Image
Caption (A, B) Lateral views of E18.5 Ptk7chz/Ptk7chz (chz/chz) fetuses demonstrate reduced cervical flexure in mutants (B) compared to wild-type (+/+) littermates (A). Lines are drawn between the mouth opening and centre of the ear, and parallel to the long axis of the spine. (C-F) Lateral (C, D) and ventral (E, F) views of wild-type (C, E) and mutant (D, F) E10.5 embryos show abnormal looping of the heart in the mutant embryo. Lines are drawn between the first branchial arches, along the base of the heart, and between the forelimb buds, indicating the abnormal flexure of the mutant embryo; the abnormal positioning of the heart appears to reflect the abnormal skewing of the embryo, likely owing to incomplete embryonic turning. The posterior region of the E10.5 embryos (caudal to the forelimb bud) have been removed to aid photography of the heart region.
Copyright This image is from Paudyal A, BMC Dev Biol 2010;10():87, an open-access article, licensee BioMed Central Ltd. J:163834
Associated
Alleles
Symbol Name
Ptk7chz PTK7 protein tyrosine kinase 7; chuzhoi
Associated
Genotypes
Allelic Composition Genetic Background
Ptk7chz/Ptk7chz involves: BALB/cAnN * C3H/HeH

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory