Phenotype Image Detail

Image

Caption

(C) Morphology of reproductive organs from 8 week old wild-type (Ing2^+/+) and Ing2^tm1.1Ccha/Ing2^tm1.1Ccha (Ing2^-/-) male mice. The seminal vesicles (black arrowheads), bladder (white arrows), epididymis (white arrowheads), testes (black arrows) are demonstrated. Scale bar, 1 cm. (D) Testis weight during postnatal development of wild-type and mutant mice. Student's t test, n = 5 per group. Error bars are s.e.m. (E) Semen in wild-type and mutant mice. Scale bars, 100 um. (F) Numbers of normal spermatozoa in semen during postnatal development of wild-type and mutant mice. Data ae mean from n = 3 (8 weeks) or n = 2 (16 and 24 weeks). Error bars are s.e.m. (G) Normal and abnormal spermatozoa from wild-type and mutant mice, respectively. The leftmost panel (wild-type) shows mature normal spermatozoon with a characteristic, hook-shaped nucleus, straight mitochondrial sheath and straight tail. The right three panels (mutant) show morphologically abnormal, immature spermatozoa, including ones with a round head and a short tail (black arrow), a large head and multiple tails (white arrow), and a tail coiled (white arrowhead). Scale bars are 50 um in the left three panels and 25 um in the rightmost panel.

Copyright

This image is from Saito M, PLoS One 2010;5(11):e15541, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:167311

Associated Alleles

Symbol	Name
Ing2^tm1.1Ccha	inhibitor of growth family, member 2; targeted mutation 1.1, Curtis C Harri

Associated Genotypes

Allelic Composition	Genetic Background
Ing2^tm1.1Ccha/Ing2^tm1.1Ccha	involves: 129 * C57BL/6J * FVB/N