Phenotype Image Detail

Image

Caption

(A-L) Wholemount in situ hybridization for Sox10 expression at E10.5 in wild-type (+/+) (A-C), heterozygous Ptk7^chz/Ptk7⁺ (chz/+) (D-F) and Ptk7^chz/ Ptk7^chz (chz/chz) homozygous mutant (G-L) embryos. Wild-type and heterozygous embryos showed normal cranial (V, VII/VIII, IX, Xj (jugular) and Xn (nodose) and dorsal root ganglia (drg). Homozygous mutants exhibit abnormally shaped trigeminal ganglia (V), and apparent fusion of the ninth (IX) and tenth (Xn) cranial ganglia. The distribution of neural crest cells in the spinal region also appears abnormal, with disturbance of the normal V-shaped arrangement of stained cells in the dorsal root ganglia. B, E, H, K are higher power views of the branchial arches (K is left side of embryo shown in J); C, F, I, L are higher power views of the dorsal root ganglia.

Copyright

This image is from Paudyal A, BMC Dev Biol 2010;10():87, an open-access article, licensee BioMed Central Ltd. J:163834

Associated Alleles

Symbol	Name
Ptk7^chz	PTK7 protein tyrosine kinase 7; chuzhoi

Associated Genotypes

Allelic Composition	Genetic Background
Ptk7^chz/Ptk7^chz	involves: BALB/cAnN * C3H/HeH