Phenotype Image Detail

Image

Caption

Progressive astrogliosis in the white matter of Tg(Notch3*R169C)88Bbb/0 mice prior to white matter disorganization and vacuolization. (A-B) Hematein & eosin staining (A) and Kluver-Barrera Luxol fast blue staining (B) in the corpus callosum, internal capsula and fimbria of the hippocampus of 12 month-old Tg(Notch3*R169C)88Bbb/0 (TgNotch3^R169C) mice showing nearly intact parenchyma. (C) GFAP staining in the corpus callosum, internal capsula and fimbria of the hippocampus of 6 (upper panels) and 12 month-old (lower panels) mutant mice showing astrogliosis in mutant mice at 12 months of age, but not at 6 months of age. (D) Quantification of astrogliosis in the cortex, corpus callosum, internal capsula and fimbria of the hippocampus of 6 and 12 month-old mutant mice compared with mice expressing wild-type Notch3 (TgNotch3^WT) (n = 4-5 mice per group). Scale bar is 65 um.

Copyright

This image is from Joutel A, J Clin Invest 2010 Feb 1;120(2):433-45 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156682

Associated Alleles

Symbol	Name
Tg(Notch3*R169C)88Bbb	transgene insertion 88, Norbert Hubner

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Notch3*R169C)88Bbb/0	involves: FVB/N