Phenotype Image Detail

Image

Caption

Autoradiograms of regional cerebral blood flow. Representative blood flow autoradiograms (sagittal brain sections) in 18 month-old mice expressing wild-type Notch3 (TgNotch3^WT) (A) and Tg(Notch3*R169C)88Bbb/0 (TgNotch3^R169C) (B) mice showing widespread reductions of blood flow in both gray and white matter regions in the mutant brain. The colored scale indicates absolute blood flow values. Abbreviations: cb, cerebellum; cc, corpus callosum; fi, fimbria of the hippocampus; ic, internal capsula; IC, inferior colliculus; SC, superior colliculus; VPM, ventral posteromedial thalamic nucleus.

Copyright

This image is from Joutel A, J Clin Invest 2010 Feb 1;120(2):433-45 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156682

Associated Alleles

Symbol	Name
Tg(Notch3*R169C)88Bbb	transgene insertion 88, Norbert Hubner

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Notch3*R169C)88Bbb/0	involves: FVB/N