Phenotype Image Detail

Image

Caption

Histopathology of lung from wild-type and Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} mice. (A) Wild-type (S1PL^+/+) lung: Alveolar spaces are generally clear and septa are thin in wild-type mice (B) Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} (S1PL^-/-) lung: Alveoli contain variably sized irregularly shaped polygonal flakes and clumps of smooth homogenous (hyaline) material accompanied by increased numbers of alveolar macrophages. Alveolar septa are mildly thickened due to cellular hypertrophy and collagen deposition. H&E stain.

Copyright

This image is from Vogel P, PLoS ONE 2009;4(1):e4112, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:145159

Associated Alleles

Symbol	Name
Sgpl1^Gt(OST58278)Lex	sphingosine phosphate lyase 1; gene trap OST58278, Lexicon Genetics
Sgpl1^tm1(SGPL1)Lex	sphingosine phosphate lyase 1; targeted mutation 1, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Sgpl1^Gt(OST58278)Lex/Sgpl1^Gt(OST58278)Lex	involves: 129S5/SvEvBrd * C57BL/6J