Phenotype Image Detail

Image

Caption

Histopathology of bone from wild-type and Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} mice. Wild-type (S1PL^+/+) Bone (A, B, and C): In wild-type mice, the majority of the marrow cavity is filled with hematopoietic elements. Widely spaced trabeculae in long bones (A) and sternum (B) extend a relatively short distance from the physeal growth plate. At higher magnification (C), normal osteoclasts appear as multinucleated cells that are usually tightly adherent and flattened against bone surfaces. Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} (S1PL^-/-) Bone (D, E, and F): In marked contrast, there is a diffuse increase in the volume and extent of trabecular bone in the long bones (D) and sternum (E) of Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} mice. The bony trabeculae extend throughout the marrow farther than normal into the diaphysis of long bones (D) and sternum (E). At higher magnification (F), the more numerous osteoclasts of Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} mice are distended by abundant pale and granular eosinophilic cytoplasm that displaces cell nuclei to the periphery. These large rounded Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} osteoblasts (arrows) have reduced direct contact with bone surfaces. H&E stain.

Copyright

This image is from Vogel P, PLoS ONE 2009;4(1):e4112, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:145159

Associated Alleles

Symbol	Name
Sgpl1^Gt(OST58278)Lex	sphingosine phosphate lyase 1; gene trap OST58278, Lexicon Genetics
Sgpl1^tm1(SGPL1)Lex	sphingosine phosphate lyase 1; targeted mutation 1, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Sgpl1^Gt(OST58278)Lex/Sgpl1^Gt(OST58278)Lex	involves: 129S5/SvEvBrd * C57BL/6J