Phenotype Image Detail

Image

Caption

Histopathology in other tissues. (A) Wild-type (S1PL^+/+) heart: There is minimal interstitial tissue in wild-type myocardium. (B) Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} (S1PL^-/-) heart: There is a patchy to diffuse expansion of the interstitium by numerous variably-sized vacuoles and vacuolated mesenchymal cells that separate the cardiomyocytes. Scattered cardiomyocytes contain indistinct foamy inclusions and sharply demarcated clear vacuoles. (C) Wild-type urinary bladder: Normal urothelium lines the urinary bladder in wild-type mice (D) Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} urinary bladder: There is widespread ballooning vacuolization, degeneration, and apoptosis of urothelial cell. Lesions are more severe in the superficial umbrella cell layer, where degenerating cells are interspersed among vacuolated urothelial cells. (E) Bone, aged Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{Gt(OST58278)Lex} (S1PL^H/-) mouse: Small numbers of distended osteoclasts are present multifocally at the growth plate only. No increase in trabecular bone was evident. (F) Urinary bladder, aged Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{Gt(OST58278)Lex} mouse: Rare vacuolated urothelial cells were present in the superficial mucosa. H&E stain.

Copyright

This image is from Vogel P, PLoS ONE 2009;4(1):e4112, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:145159

Associated Alleles

Symbol	Name
Sgpl1^Gt(OST58278)Lex	sphingosine phosphate lyase 1; gene trap OST58278, Lexicon Genetics
Sgpl1^tm1(SGPL1)Lex	sphingosine phosphate lyase 1; targeted mutation 1, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Sgpl1^Gt(OST58278)Lex/Sgpl1^Gt(OST58278)Lex	involves: 129S5/SvEvBrd * C57BL/6J
Sgpl1^Gt(OST58278)Lex/Sgpl1^tm1(SGPL1)Lex	involves: 129S5/SvEvBrd * C57BL/6J