Phenotype Image Detail

Image

Caption

Effects of Cebpb ablation in pancreatic beta cells of Lepr^db/ Lepr^db mice. (E) Pancreatic sections from 24-week-old Lepr^db/Lepr⁺ (Lepr^+/-), Lepr^db/Lepr⁺ Cebpb^tm1.1Maka/ Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 (Lepr^+/-;betaCebpb^-/-), Lepr^db/Lepr^db (Lepr^-/-) and Lepr^db/Lepr^db Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 (Lepr^-/-;betaCebpb^-/-) mice were stained with antibodies to insulin (red) and to glucagon (green). Scale bars: 100 um.

Copyright

This image is from Matsuda T, J Clin Invest 2010 Jan;120(1):115-26 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156725

Associated Alleles

Symbol	Name
Cebpb^tm1.1Maka	CCAAT/enhancer binding protein beta; targeted mutation 1.1, Masato Kasuga
Lepr^db	leptin receptor; diabetes
Tg(Ins2-cre)23Herr	transgene insertion 23, Pedro Luis Herrera

Associated Genotypes

Allelic Composition	Genetic Background
Lepr^db/Lepr^db	BKS.Cg-Dock7^m +/+ Lepr^db/Jcl
Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Lepr^db/Lepr^db Tg(Ins2-cre)23Herr/0	involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J