Phenotype Image Detail

Image

Caption

(A and B) Representative hematoxylin and eosin-stained (H&E) kidney sections showing infiltration of leukocytes (arrow) around the renal cortical vessels in 100% of Slc26a1^tm1Mark/Slc26a1^tm1Mark (Sat1-/-) mice (n = 8), absent in wild-type (Sat1+/+) mice. (C-F) Representative Yasue-stained kidney (C and D) and bladder (E and F) sections showing calcium oxalate stones (dark staining) in kidney tubules of 47% mutant mice (n = 15) and bladders of 26% mutant mice (n = 19), but not in any wild-type mice (n = 10). Gross histological analyses of additional tissues in which Slc26a1 is expressed (liver and brain) showed no structural differences between mutant and wild-type mice (not shown). Scale bars: 100 um (A and B); 500 um (C and D); 2 mm (E and F).

Copyright

This image is from Dawson PA, J Clin Invest 2010 Mar;120(3):706-12 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:158567

Associated Alleles

Symbol	Name
Slc26a1^tm1Mark	solute carrier family 26 (sulfate transporter), member 1; targeted mutation 1, Daniel Markovich

Associated Genotypes

Allelic Composition	Genetic Background
Slc26a1^tm1Mark/Slc26a1^tm1Mark	involves: 129X1/SvJ * CD-1