Phenotype Image Detail

Image

Caption

(A and B) Serum alanine aminotransferase (ALT) and liver glutathione (GSH) levels in wild-type (Sat1+/+) (white bars) and Slc26a1^tm1Mark/ Slc26a1^tm1Mark (Sat1-/-) (black bars) mice 0, 2, and 12 hours after administration of 250 mg/kg acetaminophen (APAP). Results are mean +/- SEM (n = 4-8 per group). *P < 0.05 versus time 0 wild-type; #P < 0.05 versus time 0 mutant. (C and D) Representative hematoxylin and eosin (H&E)-stained liver sections of wild-type and mutant mice (n = 6-7 per group) 12 hours after administration of 250 mg/kg APAP, showing liver necrosis in mutant mice. Scale bars: 100 um.

Copyright

This image is from Dawson PA, J Clin Invest 2010 Mar;120(3):706-12 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:158567

Associated Alleles

Symbol	Name
Slc26a1^tm1Mark	solute carrier family 26 (sulfate transporter), member 1; targeted mutation 1, Daniel Markovich

Associated Genotypes

Allelic Composition	Genetic Background
Slc26a1^tm1Mark/Slc26a1^tm1Mark	involves: 129X1/SvJ * CD-1