Phenotype Image Detail

Image

Caption

Klf5^tm2.1Rng/ Klf5^tm2.1Rng (Klf5^fl/fl), and Klf5^tm2.1Rng/Klf5^tm2.1Rng Tg(Myh6-cre)2182Mds/0 (Klf5^fl/fl; alphaMHC-Cre) mice were subjected to low-intensity transverse aortic constriction (LI-TAC) or sham operation. (A) Representative low-magnification views of hematoxylin and eosin (H&E)-stained heart sections 2 weeks after LI-TAC. Scale bar: 1 mm. (B and C) Heart weight/body weight ratios (B) and relative cross-sectional areas of cardiomyocytes normalized to those obtained from Klf5^tm2.1Rng/ Klf5^tm2.1Rng mice subjected to sham operations (C). (D) Fractional areas of fibrosis. *P < 0.01 versus sham control of the same genotype. n = 7.

Copyright

This image is from Takeda N, J Clin Invest 2010 Jan;120(1):254-65 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156696

Associated Alleles

Symbol	Name
Klf5^tm2.1Rng	Kruppel-like transcription factor 5; targeted mutation 2.1, Ryozo Nagai
Tg(Myh6-cre)2182Mds	transgene insertion 2182, Michael D Schneider

Associated Genotypes

Allelic Composition	Genetic Background
Klf5^tm2.1Rng/Klf5^tm2.1Rng Tg(Myh6-cre)2182Mds/0	involves: C57BL/6 * FVB/N