Phenotype Image Detail

Image

Caption

Mice homozygous for the dumbo mutation (Hmx1^dmbo/ Hmx1^dmbo) have low set, laterally protruding ears. They are smaller in overall body size than normal, with males weighing about half that of normal littermates at three days of age and lagging behind through nine days of age. Most have microphthalmia. This mutation causes perinatal lethality such that approximately 40% fewer homozygotes than predicted by standard Mendelian genetics are found at three weeks of age. Further assessment showed that most of the homozygous death occurs within the first three days of life and is strongly associated with exencephaly. This strain is a model of oculo-auricular syndrome.

Copyright

Photo courtesy of Mouse Mutant Resource at the Jackson Laboratory. https://www.jax.org/research-and-faculty/tools/mouse-mutant-resource J:110244

Associated Alleles

Symbol	Name
Hmx1^dmbo	H6 homeobox 1; dumbo