Phenotype Image Detail

Image

Caption

Transgenic mice expressing the SV40 T antigen A under the control of urothelium-specific UPK II promoter (Tg(Upk2-TAg)1Rkl/0; UPKII-SV40) spontaneously developed urothelial carcinoma in situ. A, chimeric gene consisting in the UPK II promoter, the SV40 T antigen, and a polyadenylation signal. B-D, macroscopic aspect of a tumor involving the whole bladder (white arrow) in a 5-month old Tg(Upk2-TAg)1Rkl/0 mouse (B) when compared with normal bladder in a wild-type (WT) littermate (C, white arrow). E, evolution of bladder weight (in mg) in transgenic and WT mice, significantly increased in males. F-O, bladder urothelial carcinomas in situ (CIS) was evident since 1 week of age and grew progressively without muscle invasion or metastasis. P and Q, immunohistochemistry for SV40 antigen showing the urothelium-specific expression of SV40 in mutant mice. R, high-power H&E-stained sections showing an area of urothelial CIS with large and pleomorphic nuclei and loss of cell polarity. S-V, CIS in the renal pelvis (S and T) and ureter (U-V), of mutant mice when compared with normal urothelium in littermate controls.

Copyright

This image is from Ayala de la Pena F, J Biol Chem 2011 Jun 10;286(23):20778-87 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:173505

Associated Alleles

Symbol	Name
Tg(Upk2-TAg)1Rkl	transgene insertion 1, Raghu Kalluri

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Upk2-TAg)1Rkl/0	involves: C57BL/6