Phenotype Image Detail

Image

Caption

(B-C) Pinx1^tm1.1Kplu/Pinx1⁺ heterozygous knockout leads to anaphase bridges and chromosome instability at late passage. MEFs derived from wild-type (+/+) and heterozygous (+/-) littermates were continuously cultured using the 3T3 protocol and fixed at early (from 3 to 5) or late (~30) passage, followed by staining with DAPI to score for the frequency of anaphase bridges and/or lagging chromosomes (B) and by counting the number of chromosomes at metaphase chromosome spreads to score for aneuploidy (C).

Copyright

This image is from Zhou XZ, J Clin Invest 2011 Apr 1;121(4):1266-82 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171997

Associated Alleles

Symbol	Name
Pinx1^tm1.1Kplu	PIN2/TERF1 interacting, telomerase inhibitor 1; targeted mutation 1.1, Kun Ping Lu

Associated Genotypes

Allelic Composition	Genetic Background
Pinx1^tm1.1Kplu/Pinx1^+	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N