Phenotype Image Detail

Image

Caption

(I-J) Chromosome instability in Pinx1^tm1.1Kplu/Pinx1⁺ MEFs at late passages. Insets show examples of chromosome translocations (left to right), the display color, the inverted DAPI counterstain, and the classification pseudocolor. Arrows in I and J point to chromosome fusions, while red arrows in insets point to centrosomes. Numbers indicate the chromosomal origin of each fragment. Insets in I show 3 examples of translocations between short arms of 2 different chromosomes, with each containing a centromere, while inset in J shows an example of a translocation between long arms of 2 different chromosomes, with 1 containing a centromere.

Copyright

This image is from Zhou XZ, J Clin Invest 2011 Apr 1;121(4):1266-82 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171997

Associated Alleles

Symbol	Name
Pinx1^tm1.1Kplu	PIN2/TERF1 interacting, telomerase inhibitor 1; targeted mutation 1.1, Kun Ping Lu

Associated Genotypes

Allelic Composition	Genetic Background
Pinx1^tm1.1Kplu/Pinx1^+	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N