Phenotype Image Detail

Image

Caption

(A and B) Ventral view of wild-type (control, WT) and Porcn^tm1.1Lcm/Porcn⁺ Edil3^{Tg(Sox2-cre)1Amc}/0 (Porcn^delta/+) littermates at weanling stage (postnatal day 22). (C-E) Whole-mount in situ hybridization for Lef1 (brown) on shoulder region of E14.5 control or mutant embryos. The asterisk indicates a fragment of skin accidentally removed during dissection. (E) Dorsal view of an E17.5 mutant embryo, indicating patches of unusually smooth skin (arrowheads). (F-M) Semiadjacent sections of dorsal skin from E17.5 WT or mutant embryos, stained with H&E or immunostained for Lef1 or p63. The brackets in I indicate patches devoid of hair follicles and expressing low or no Lef1. hf, hair follicle. (Scale bars: 100 um.)

Copyright

This image is from Barrott JJ, Proc Natl Acad Sci U S A 2011 Jul 18;():. Copyright 2011 National Academy of Sciences, U.S.A. J:173672

Associated Alleles

Symbol	Name
Edil3^Tg(Sox2-cre)1Amc	EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Porcn^tm1.1Lcm	porcupine O-acyltransferase; targeted mutation 1.1, Lewis Murtaugh

Associated Genotypes

Allelic Composition	Genetic Background
Porcn^tm1.1Lcm/Porcn^+ Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA