Phenotype Image Detail

Image

Caption

(Q-T) Different tumor grades next to each other in the same section of lung cancer in Pinx1^tm1.1Kplu/Pinx1⁺ mice (Q). (R) Highly undifferentiated and aggressive (high grade) adenocarcinoma cells with huge nuclei. (S) Intermediately differentiated and aggressive (intermediate grade) adenocarcinoma cells with intermediate nuclei; (T) well-differentiated and less aggressive (low grade) adenocarcinoma cells with small nuclei. Red arrows point to different sizes of nuclei; blue arrows point to mitotic cancer cells. Original magnification, x40 (Q); x60 (R-T).

Copyright

This image is from Zhou XZ, J Clin Invest 2011 Apr 1;121(4):1266-82 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171997

Associated Alleles

Symbol	Name
Pinx1^tm1.1Kplu	PIN2/TERF1 interacting, telomerase inhibitor 1; targeted mutation 1.1, Kun Ping Lu

Associated Genotypes

Allelic Composition	Genetic Background
Pinx1^tm1.1Kplu/Pinx1^+	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N