Phenotype Image Detail

Image

Caption

(A) Sox9 staining of the intestine in Col1a1^{tm1(tetO-Tcfap2c)Hsc}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺ (iTcfap2c; upper panel) and control (ctrl; lower panel) mice. (B) Alcian blue-PAS staining of the mutant intestine (upper panel) and controls (lower panel). Arrowheads indicate Paneth cells, found at the bottom of the crypts by blue coloring of their granules. Scale bar = 100 um.

Copyright

This image is from Holl D, PLoS One 2011;6(7):e22034, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:174049

Associated Alleles

Symbol	Name
Col1a1^tm1(tetO-Tcfap2c)Hsc	collagen, type I, alpha 1; targeted mutation 1, Hubert Schorle
Gt(ROSA)26Sor^tm1(rtTA*M2)Jae	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Rudolf Jaenisch

Associated Genotypes

Allelic Composition	Genetic Background
Col1a1^tm1(tetO-Tcfap2c)Hsc/Col1a1^+ Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/Gt(ROSA)26Sor^+	involves: 129S4/SvJae * C57BL/6